Upcoming Events
Christelle Remy, BScn
MUHC Cancer Pain Program
Symptom management through phone calls. The Cancer Pain Clinic experience
May 22, 2019 4:00 p.m.
MGH Room A5-131
The Philip R. Bromage Anesthesia Research Day
Dept of Anesthesia Annual Research Day
June 13, 2019 4:00 p.m.
MUHC Glen Site, Room 2.28
Featured Events
David Ginty, PhD, Harvard Medicial School
Oct 10 2019, 4:00 p.m.
Jeanne Timmins Amphitheatre, MNI
2019 Aguayo Lecture: The Sensory Neurons of Touch
[link]
Featured Paper Archive
  • Ferland CE, Teles AR, Ingelmo P, Saran N, Marchand S, Ouellet JA Blood monoamines as potential biomarkers for conditioned pain modulation efficacy: An exploratory study in paediatrics. Eur J Pain. 2019 Feb;23(2):327-340. doi: 10.1002/ejp.1307 [link]
  • Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Mar 15;14:47-57. doi: 10.1016/j.isci.2019.03.011 [link]
  • He BH, Christin M, Mouchbahani-Constance S, Davidova A, Sharif-Naeini R, Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis Osteoarthritis and Cartilage, Dec. 2017, 25(12):2091-2099 [link]
  • George NC, Laferriere A, Coderre T. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019 Mar 11:1744806919840582. doi: 10.1177/1744806919840582 [link]
  • Baird R, Ingelmo P, Wei A, Meghani Y, Perez EV, Pelletier H, Auer G, Mujallid R, Emil S, Laberge JM, Puligandla P, Shaw K, Poenaru D. Nebulized analgesia during laparoscopic appendectomy (NALA): A randomized triple-blind placebo controlled trial J Pediatr Surg. 2019 Jan;54(1):33-38. doi: 10.1016/j.jpedsurg.2018.10.029 [link]
  • Wideman TH, Edwards RR, Walton DM, Martel MO, Hudon A, Seminowicz DA. The Multi-modal Assessment Model of Pain: A Novel Framework for Further Integrating the Subjective Pain Experience within Research and Practice. Clin J Pain. 2018 Nov 15. doi: 10.1097/AJP.0000000000000670 [link]
  • James G, Millecamps M, Stone LS, Hodges PW.Dysregulation of the Inflammatory Mediators in the Multifidus Muscle After Spontaneous Intervertebral Disc Degeneration SPARC-null Mice is Ameliorated by Physical Activity. Spine. 2018 Oct 15;43(20):E1184-E1194. doi: 10.1097/BRS.0000000000002656. [link]
  • Tuttle AH, Philip VM, Chesler EJ, Mogil JS.Comparing phenotypic variation between inbred and outbred mice.Nat Methods. 2018 Dec;15(12):994-996. doi: 10.1038/s41592-018-0224-7. [link]
  • Miller J, Barber D, Donnelly C, French S, Green M, Hill J, MacDermid J, Marsh J, Norman K, Richardson J, Taljaard M, Wideman T, Cooper L, McPhee C. Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial Trials. 2017 Nov 9;18(1):526. doi: 10.1186/s13063-017-2279-7 [link]
  • Khoutorsky A, Uttam S, Wong C, Price TJ. eIF4E-dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity Front. Genet. | doi: 10.3389/fgene.2018.00470 [link]
  • Gélinas C., Boitor M., Puntillo K.A., Arbour C., Topolovec-Vranic J., Cusimano M.D., Choinière M., Streiner D.L. Behaviors indicative of pain in brain-injured adult patients with different levels of consciousness in the intensive care unit. J Pain Symptom Manage. 2018 Dec 26. pii: S0885-3924(18)31481-7. doi: 10.1016/j.jpainsymman.2018.12.333 [link]
  • Krock E, Millecamps M, Anderson KM, Srivastava A, Reihsen TE, Hari P, Sun YR, Jang SH, Wilcox GL, Belani KG, Beebe DS, Ouellet J, Pinto MR, Kehl LJ, Haglund L, Stone LS. Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine. 2019 Apr 29. pii: S2352-3964(19)30271-3. [link]
  • Ehrlich AT, Kieffer BL, Darcq E Current strategies toward safer mu opioid receptor drugs for pain management Expert Opin Ther Targets. 2019 Feb 25. doi: 10.1080/14728222.2019.1586882 [link]
  • Kathleen Vincent, Virginia M. Cornea, Yuh-Jiin I. Jong, André Laferrière, Naresh Kumar, Aiste Mickeviciute, Jollee S. T. Fung, Pouya Bandegi, Alfredo Ribeiro-da-Silva, Karen L. O’Malley & Terence J. Coderre Intracellular mGluR5 plays a critical role in neuropathic pain doi:10.1038/ncomms10604 (2016) [link]
  • Häuser W, Sarzi-Puttini P, Fitzcharles MA. Fibromyalgia syndrome: under-, over- and misdiagnosis Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8 [link]
  • Beaudry H, Daou I, Ase AR, Ribeiro-da-Silva A, Séguéla P. Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers Pain. 2017 Dec;158(12):2329-2339. doi: 10.1097/j.pain.0000000000001016 [link]
  • Roy, M., Vachon-Presseau, E. Cortisol increases visceral pain in women but not in men. Pain. 2019 Apr 6. doi: 10.1097/j.pain.0000000000001580 [link]
  • James G, Klyne DM, Millecamps M, Stone LS, Hodges PW.ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. Eur Spine J. 2019 Feb 8. doi: 10.1007/s00586-019-05902-9. [link]
  • Martel MO, Petersen K, Cornelius M, Arendt-Nielsen L, Edwards R. Endogenous pain modulation profiles among individuals with chronic pain: Relation to opioid use. J Pain. 2018 Oct 29. pii: S1526-5900(18)30759-4. doi: 10.1016/j.jpain.2018.10.004. [link]
  • Hochberg U, Ojeda A, Brill S, Perez J An internet based survey to assess clinicians' knowledge and attitudes towards opioid induced hypogonadism. Pain Pract. 2018 Sep 30. doi: 10.1111/papr.12731. [link]
  • Anne-Kathrin Brascher, Susanne Becker, Marie-Eve Hoeppli, Petra Schweinhardt Different Brain Circuitries Mediating Controllable and Uncontrollable Pain The Journal of Neuroscience 36(18):5013–5025 (2016) [link]
  • Mouchbahani-Constance S, Lesperance, LS, Petitjean H,Davidova A, Macpherson A, Prescott SA, Sharif-Naeini R. Lionfish Venom Elicits Pain Predominantly Through the Activation of Non-Peptidergic Nociceptors PAIN: June 29, 2018, doi: 10.1097/j.pain.0000000000001326 [link]
  • Yakobov E., Suso-Ribera C., Vrinceanu T., Adams H., Sullivan MJL. Trait perceived injustice is associated with pain intensity and pain behaviour in participants undergoing an experimental pain induction procedureJ Pain, Nov 2018, https://doi.org/10.1016/j.jpain.2018.11.007 [link]
  • Piltonen M, Parisien M, Grégoire S, Chabot-Doré AJ, Jafarnejad SM, Bérubé P, Djambazian H, Sladek R, Geneau G, Willett P, Stone LS, Shabalina SA, Diatchenko L. Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms Mol Neurobiol. 2018 Jul 31. doi: 10.1007/s12035-018-1253-z. [link]
  • Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human disease. Nat Rev Mol Cell Biol. 2018 Jul 23. doi: 10.1038/s41580-018-0034-x [link]
  • Cordeiro Matos S, Zamfir M, Longo G, Ribeiro-da-Silva A, Séguéla P. Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex Brain Struct Funct.doi: 10.1007/s00429-017-1543-7 (Nov 2017) [link]
  • Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N. Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis JAMA Psychiatry. 2019 Feb 13. doi: 10.1001/jamapsychiatry.2018.4500 [link]
  • Smith SB et al. Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain. 2018 Nov 13. doi: 10.1097/j.pain.0000000000001438 [link]
  • Ware M.A., Martel M.O., Jovey R., Lynch M.E., Singer J. A prospective observational study of problematic oral cannabinoid use. Psychopharmacology (Berl). 2018 Feb;235(2):409-417. doi: 10.1007/s00213-017-4811-6. Epub 2017 Dec 17. [link]
  • Martin LJ, Acland EL, Cho C, Gandhi W, Chen D, Corley E, Kadoura B, Levy T, Mirali S, Tohyama S, Khan S, MacIntyre LC, Carlson EN, Schweinhardt P, Mogil JS. Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans. Curr Biol. 2019 Jan 21;29(2):192-201.e4. doi: 10.1016/j.cub.2018.11.030. Epub 2019 Jan 10 [link]
  • Ihab Daou, Hélène Beaudry, Ariel R. Ase, Jeffrey S. Wieskopf, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Philippe Séguéla Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain DOI: 10.1523/ENEURO.0140-15 (2016) [link] [File]
  • Khoutorsky A, Price TJ. Translational Control Mechanisms in Persistent Pain Trends Neurosci. 2017 Dec 14. pii: S0166-2236(17)30233-3. doi: 10.1016/j.tins.2017.11.006 [link]
  • Massart R, Dymov S, Millecamps M, Suderman M, Gregoire S, Koenigs K, Alvarado S, Tajerian M, Stone LS, Szyf M. Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells. Sci Rep. doi: 10.1038/srep19615 (2016) [link]
  • Tansley, S.N., Macintyre, L. C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J-S., Coderre, T.J., Martin, L.J.,Mogil, J.S.Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity PAIN: December 03, 2018, doi: 10.1097/j.pain.0000000000001454 [link]
  • Coderre TJ, Topical drug therapeutics for neuropathic pain. Expert Opin Pharmacother. Aug 2018. 19(11):1211-1220. doi: 10.1080/14656566.2018.1501026. [link]
  • Parisien, Marc, Samoshkin, Alexander, Tansley, Shannon N, Piltonen, Marjo H, Martin, Loren J, El-Hachem, Nehme, Dagostino, Concetta, Allegri, Massimo, Mogil, Jeffrey S, Khoutorsky, Arkady,Diatchenko, Luda. Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain PAIN: January 03, 2019 - in Press. doi: 10.1097/j.pain.0000000000001471 [link]