Upcoming Events
Irina Kudrina, MD, CM, CCFP
Dept of Family Medicine, McGill University
Toxic stress of pain and chronic exogenous cannabinoid & opioid toxicity
December 18, 2019 4:00 p.m.
MGH Room A5-131
Dr. Mogil's Lab
January 16, 2020 9:30 a.m.
McIntyre Medical Room 1346
David Bennett
Professor of Neurology & Neurobiology, Oxford University
Human Pain Channelopathies - for more info on McGill Pain Day, see below
January 23, 2020 12:00 p.m.
New Residence Hall, 3625 ave du Parc
Catherine Cahill, PhD
UCLA
Intersection between pain and addiction: implications for kappa opioid receptors
February 19, 2020 4:00 p.m.
MGH Room A5-131
Robert Gereau, PhD,
Dept of Anesthesiology, Washington University
Basic Science of Pain Lecture series: TBA
March 13, 2020 11:00 a.m.
Physiology 1034
Featured Events
Montreal Neuroinflammation Symposium
Dec 13 2019, 8:30 a.m.
Timmins Amphitheatre, MNI
Neuroinflammation and its role in a wide variety of healthcare problems (pain, MS, mental illness, etc.)
[link]
24th Annual McGill Pain Day - with David Bennett, Oxford University, as Keynote speaker
Jan 23 2020, 12:00-16:30
McGill Residence Hall, 3624 Avenue du Parc
The annual research day celebrating the varied and important research undertaken by our members. Registration is free but is required for planning purposes. Please use the link below to register.
[link]
#CanadianPain20
May 19 2020
Calgary, Alberta
The 41st annual meeting of the Canadian Pain Society, May 19-22, 2020
[link]
World Congress on Pain 2020
Aug 04 2020
Amsterdam, The Netherlands
The 18th WCP organized by the International Association for the Study of Pain from August 4th to the 8th -- be there!
[link]
Featured Paper Archive
  • Pagé MG, Ziemianski D, Martel MO, Shir Y. Development and validation of the Treatment Expectations in Chronic Pain Scale. Br J Health Psychol. 2019 Sep;24(3):610-628. doi: 10.1111/bjhp.12371 [link]
  • Roy, M., Vachon-Presseau, E. Cortisol increases visceral pain in women but not in men. Pain. 2019 Apr 6. doi: 10.1097/j.pain.0000000000001580 [link]
  • Hochberg U, Ojeda A, Brill S, Perez J An internet based survey to assess clinicians' knowledge and attitudes towards opioid induced hypogonadism. Pain Pract. 2018 Sep 30. doi: 10.1111/papr.12731. [link]
  • Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Mar 15;14:47-57. doi: 10.1016/j.isci.2019.03.011 [link]
  • K Herr, PJ Coyne, E Ely, C Gélinas, RCB Manworren Pain Assessment in the Patient Unable to Self-Report: Clinical Practice Recommendations in Support of the ASPMN 2019 Position Statement Pain Management Nursing, 2019 Oct 11. pii: S1524-9042(19)30162-6 [link]
  • Ihab Daou, Hlne Beaudry, Ariel R. Ase, Jeffrey S. Wieskopf, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Philippe Sgula Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain DOI: 10.1523/ENEURO.0140-15 (2016) [link] [File]
  • Devlin JW, Skrobki Y, Gelinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-e873. doi: 10.1097 [link]
  • Yakobov E., Suso-Ribera C., Vrinceanu T., Adams H., Sullivan MJL. Trait perceived injustice is associated with pain intensity and pain behaviour in participants undergoing an experimental pain induction procedureJ Pain, Nov 2018, https://doi.org/10.1016/j.jpain.2018.11.007 [link]
  • Pomares FB, Roy S, Funck T, Feier NA, Thiel A, Fitzcharles MA, Schweinhardt P. Up-regulation of cortical GABAA receptor concentration in fibromyalgia. Pain. 2019 Sep 27. doi: 10.1097/j.pain.0000000000001707. [link]
  • Martel MO, Petersen K, Cornelius M, Arendt-Nielsen L, Edwards R. Endogenous pain modulation profiles among individuals with chronic pain: Relation to opioid use. J Pain. 2018 Oct 29. pii: S1526-5900(18)30759-4. doi: 10.1016/j.jpain.2018.10.004. [link]
  • Huser W, Sarzi-Puttini P, Fitzcharles MA. Fibromyalgia syndrome: under-, over- and misdiagnosis Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8 [link]
  • Grégoire S, Jang SH, Szyf M, Stone LS. Prenatal maternal stress is associated with increased sensitivity to neuropathic pain and sex-specific changes in supraspinal mRNA expression of epigenetic- and stress-related genes in adulthood. Behav Brain Res. 2019 Nov 28:112396. doi: 10.1016/j.bbr.2019.112396. [link]
  • Ferland CE, Teles AR, Ingelmo P, Saran N, Marchand S, Ouellet JA Blood monoamines as potential biomarkers for conditioned pain modulation efficacy: An exploratory study in paediatrics. Eur J Pain. 2019 Feb;23(2):327-340. doi: 10.1002/ejp.1307 [link]
  • Roy M, Vachon-Presseau É. Cortisol increases visceral pain in women but not in men. Pain. 2019 Aug;160(8):1691-1692. [link]
  • Petitjean H, B Bourojeni F, Tsao D, Davidova A, Sotocinal SG, Mogil JS, Kania A, Sharif-Naeini R. Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons Cell Rep. 2019 Aug 6;28(6):1429-1438.e4 [link]
  • Woznowski-Vu A, Uddin Z, Flegg D, Aternali A, Wickens R, Sullivan MJL, Sweet SN, Skou ST, Wideman TH.Comparing Novel and Existing Measures of Sensitivity to Physical Activity among People With Chronic Musculoskeletal Pain: The Importance of Tailoring Activity to Pain. Clin J Pain. 2019 May 27. doi: 10.1097/AJP.0000000000000732 [link]
  • Federico CA, Wang T, Doussau A, Mogil JS, Fergusson D, Kimmelman J. Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review. JAMA Intern Med. 2019 Jan 1;179(1):90-97. [link]
  • Fitzcharles MA, Shir Y, Häuser W. Medical cannabis: strengthening evidence in the face of hype and public pressure. CMAJ. 2019 Aug 19;191(33):E907-E908 [link]
  • Khoury S, Piltonen MH, Ton AT, Cole T, Samoshkin A, Smith SB, Belfer I, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, Neely GG, Serohijos AWR, Diatchenko L. A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway. Ann Neurol. 2019 Jun 8. doi: 10.1002/ana.25521 [link]
  • Kathleen Vincent, Virginia M. Cornea, Yuh-Jiin I. Jong, Andr Laferrire, Naresh Kumar, Aiste Mickeviciute, Jollee S. T. Fung, Pouya Bandegi, Alfredo Ribeiro-da-Silva, Karen L. OMalley & Terence J. Coderre Intracellular mGluR5 plays a critical role in neuropathic pain doi:10.1038/ncomms10604 (2016) [link]
  • Ehrlich AT, Kieffer BL, Darcq E Current strategies toward safer mu opioid receptor drugs for pain management Expert Opin Ther Targets. 2019 Feb 25. doi: 10.1080/14728222.2019.1586882 [link]
  • Martin LJ, Acland EL, Cho C, Gandhi W, Chen D, Corley E, Kadoura B, Levy T, Mirali S, Tohyama S, Khan S, MacIntyre LC, Carlson EN, Schweinhardt P, Mogil JS. Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans. Curr Biol. 2019 Jan 21;29(2):192-201.e4. doi: 10.1016/j.cub.2018.11.030. Epub 2019 Jan 10 [link]
  • George NC, Laferriere A, Coderre T. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019 Mar 11:1744806919840582. doi: 10.1177/1744806919840582 [link]
  • Minerbi A, Gonzalez E, Brereton NJB, Anjarkouchian A, Dewar K, Fitzcharles MA, Chevalier S, Shir Y. Altered microbiome composition in individuals with fibromyalgia. Pain. 2019 Jun 18. doi: 10.1097/j.pain.0000000000001640 [link]
  • Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N. Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis JAMA Psychiatry. 2019 Feb 13. doi: 10.1001/jamapsychiatry.2018.4500 [link]
  • Coderre TJ, Topical drug therapeutics for neuropathic pain. Expert Opin Pharmacother. Aug 2018. 19(11):1211-1220. doi: 10.1080/14656566.2018.1501026. [link]
  • Anne-Kathrin Brascher, Susanne Becker, Marie-Eve Hoeppli, Petra Schweinhardt Different Brain Circuitries Mediating Controllable and Uncontrollable Pain The Journal of Neuroscience 36(18):50135025 (2016) [link]
  • Vlaeyen JWS, Maher CG, Wiech K, Van Zundert J, Meloto CB, Diatchenko L, Battié MC, Goossens M, Koes B, Linton SJ. Low back pain Nat Rev Dis Primers. 2018 Dec 13;4(1):52. doi: 10.1038/s41572-018-0052-1. [link]
  • Beaudry H, Daou I, Ase AR, Ribeiro-da-Silva A, Sgula P. Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers Pain. 2017 Dec;158(12):2329-2339. doi: 10.1097/j.pain.0000000000001016 [link]
  • Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ. Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain. J Neurosci. 2019 Jan 16;39(3):393-411 [link]
  • Mogil, JS. The translatability of pain across species. Philos Trans R Soc Lond B Biol Sci. 2019 Nov 11;374(1785):20190286. doi: 10.1098/rstb.2019.0286 [link]
  • Mouchbahani-Constance S, Lesperance, LS, Petitjean H,Davidova A, Macpherson A, Prescott SA, Sharif-Naeini R. Lionfish Venom Elicits Pain Predominantly Through the Activation of Non-Peptidergic Nociceptors PAIN: June 29, 2018, doi: 10.1097/j.pain.0000000000001326 [link]
  • Piltonen M, Parisien M, Grgoire S, Chabot-Dor AJ, Jafarnejad SM, Brub P, Djambazian H, Sladek R, Geneau G, Willett P, Stone LS, Shabalina SA, Diatchenko L. Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms Mol Neurobiol. 2018 Jul 31. doi: 10.1007/s12035-018-1253-z. [link]
  • Khoutorsky A, Uttam S, Wong C, Price TJ. eIF4E-dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity Front. Genet. | doi: 10.3389/fgene.2018.00470 [link]
  • López-Canul M, Min SH, Posa L, De Gregorio D, Bedini A, Spadoni G, Gobbi G, Comai S. Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle. Int J Mol Sci. 2019 May 17;20(10). pii: E2452. doi: 10.3390/ijms20102452. [link]
  • Coderre TJ, Laferrière A., The emergence of animal models of chronic pain and logistical and methodological issues concerning their use. Neural Transm (Vienna). 2019 Nov 18. doi: 10.1007/s00702-019-02103-y. [link]
  • Häuser W, Welsch P, Klose P, Radbruch L, Fitzcharles MA. Efficacy, tolerability and safety of cannabis-based medicines for cancer pain : A systematic review with meta-analysis of randomised controlled trials. Schmerz. 2019 Oct;33(5):424-436. doi: 10.1007/s00482-019-0373-3. [link]
  • Tuttle AH, Philip VM, Chesler EJ, Mogil JS.Comparing phenotypic variation between inbred and outbred mice.Nat Methods. 2018 Dec;15(12):994-996. doi: 10.1038/s41592-018-0224-7. [link]
  • Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human disease. Nat Rev Mol Cell Biol. 2018 Jul 23. doi: 10.1038/s41580-018-0034-x [link]
  • Cordeiro Matos S, Zamfir M, Longo G, Ribeiro-da-Silva A, Sgula P. Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex Brain Struct Funct.doi: 10.1007/s00429-017-1543-7 (Nov 2017) [link]
  • Khoutorsky A, Price TJ. Translational Control Mechanisms in Persistent Pain Trends Neurosci. 2017 Dec 14. pii: S0166-2236(17)30233-3. doi: 10.1016/j.tins.2017.11.006 [link]
  • Baird R, Ingelmo P, Wei A, Meghani Y, Perez EV, Pelletier H, Auer G, Mujallid R, Emil S, Laberge JM, Puligandla P, Shaw K, Poenaru D. Nebulized analgesia during laparoscopic appendectomy (NALA): A randomized triple-blind placebo controlled trial J Pediatr Surg. 2019 Jan;54(1):33-38. doi: 10.1016/j.jpedsurg.2018.10.029 [link]
  • Smith SB et al. Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain. 2018 Nov 13. doi: 10.1097/j.pain.0000000000001438 [link]
  • Hodges PW, Barbe MF, Loggia ML, Nijs J, Stone LS. Diverse Role of Biological Plasticity in Low Back Pain and Its Impact on Sensorimotor Control of the Spine. J Orthop Sports Phys Ther. 2019 Jun;49(6):389-401. doi: 10.2519/jospt.2019.8716 [link]
  • Krock E, Millecamps M, Anderson KM, Srivastava A, Reihsen TE, Hari P, Sun YR, Jang SH, Wilcox GL, Belani KG, Beebe DS, Ouellet J, Pinto MR, Kehl LJ, Haglund L, Stone LS. Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine. 2019 Apr 29. pii: S2352-3964(19)30271-3. [link]
  • Miller J, Barber D, Donnelly C, French S, Green M, Hill J, MacDermid J, Marsh J, Norman K, Richardson J, Taljaard M, Wideman T, Cooper L, McPhee C. Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial Trials. 2017 Nov 9;18(1):526. doi: 10.1186/s13063-017-2279-7 [link]
  • Massart R, Dymov S, Millecamps M, Suderman M, Gregoire S, Koenigs K, Alvarado S, Tajerian M, Stone LS, Szyf M. Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells. Sci Rep. doi: 10.1038/srep19615 (2016) [link]
  • Deslauriers S, Roy JS, Bernatsky S, Feldman DE, Pinard AM, Desmeules F, Fitzcharles MA, Perreault K. Factors associated with waiting times for persons with rheumatic conditions in multidisciplinary pain treatment facilities. J Pain Res. 2019 Jul 30;12:2379-2390. doi: 10.2147 [link]
  • Mohand-Saïd S, Lalonde MR, Boitor M, Gélinas C. Family Members' Experiences with Observing Pain Behaviors Using the Critical-Care Pain Observation Tool. Pain Manag Nurs. 2019 May 17. pii: S1524-9042(18)30233-9 [link]
  • He BH, Christin M, Mouchbahani-Constance S, Davidova A, Sharif-Naeini R, Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis Osteoarthritis and Cartilage, Dec. 2017, 25(12):2091-2099 [link]
  • Benavides R, Vsevolozhskaya O, Cattaneo S, Zaykin D, Brenton A, Parisien M, Verma V, Khoury S, Gilron I, Diatchenko L. A functional polymorphism in the ABCB1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. Pain. 2019 Nov 11. doi: 10.1097/j.pain.0000000000001750 [link]
  • James G, Millecamps M, Stone LS, Hodges PW.Dysregulation of the Inflammatory Mediators in the Multifidus Muscle After Spontaneous Intervertebral Disc Degeneration SPARC-null Mice is Ameliorated by Physical Activity. Spine. 2018 Oct 15;43(20):E1184-E1194. doi: 10.1097/BRS.0000000000002656. [link]
  • Tansley, S.N., Macintyre, L. C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J-S., Coderre, T.J., Martin, L.J.,Mogil, J.S.Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity PAIN: December 03, 2018, doi: 10.1097/j.pain.0000000000001454 [link]
  • Parisien, Marc, Samoshkin, Alexander, Tansley, Shannon N, Piltonen, Marjo H, Martin, Loren J, El-Hachem, Nehme, Dagostino, Concetta, Allegri, Massimo, Mogil, Jeffrey S, Khoutorsky, Arkady,Diatchenko, Luda. Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain PAIN: January 03, 2019 - in Press. doi: 10.1097/j.pain.0000000000001471 [link]
  • James G, Klyne DM, Millecamps M, Stone LS, Hodges PW.ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. Eur Spine J. 2019 Feb 8. doi: 10.1007/s00586-019-05902-9. [link]
  • Glinas C., Boitor M., Puntillo K.A., Arbour C., Topolovec-Vranic J., Cusimano M.D., Choinire M., Streiner D.L. Behaviors indicative of pain in brain-injured adult patients with different levels of consciousness in the intensive care unit. J Pain Symptom Manage. 2018 Dec 26. pii: S0885-3924(18)31481-7. doi: 10.1016/j.jpainsymman.2018.12.333 [link]
  • Wideman TH, Edwards RR, Walton DM, Martel MO, Hudon A, Seminowicz DA. The Multi-modal Assessment Model of Pain: A Novel Framework for Further Integrating the Subjective Pain Experience within Research and Practice. Clin J Pain. 2018 Nov 15. doi: 10.1097/AJP.0000000000000670 [link]
  • Ware M.A., Martel M.O., Jovey R., Lynch M.E., Singer J. A prospective observational study of problematic oral cannabinoid use. Psychopharmacology (Berl). 2018 Feb;235(2):409-417. doi: 10.1007/s00213-017-4811-6. Epub 2017 Dec 17. [link]