Upcoming Events
Ann Gamsa, PhD
Psychedelic treatment for depression and anxiety: research update
June 3, 2020 4:00 p.m.
MGH Room A5-131
Featured Events
World Congress on Pain 2020
Aug 04 2020
Amsterdam, The Netherlands
The 18th WCP organized by the International Association for the Study of Pain from August 4th to the 8th -- be there!
Featured Paper Archive
  • Martin JH, Hall W, Fitzcharles MA, Borgelt L, Crippa J. Ensuring access to safe, effective, and affordable cannabis-based medicines. Br J Clin Pharmacol. 2020 Mar 3. doi: 10.1111/bcp.14242 [link]
  • Ye DL, Plante I, Roy M, Ouellet JA, Ferland CE., The Tampa Scale of Kinesiophobia: Structural Validation among Adolescents with Idiopathic Scoliosis Undergoing Spinal Fusion Surgery. Phys Occup Ther Pediatr. 2020 Feb 7:1-11. doi: 10.1080/01942638.2020.1720054 [link]
  • Miller J, Barber D, Donnelly C, French S, Green M, Hill J, MacDermid J, Marsh J, Norman K, Richardson J, Taljaard M, Wideman T, Cooper L, McPhee C. Determining the impact of a new physiotherapist-led primary care model for back pain: protocol for a pilot cluster randomized controlled trial Trials. 2017 Nov 9;18(1):526. doi: 10.1186/s13063-017-2279-7 [link]
  • James G, Millecamps M, Stone LS, Hodges PW.Dysregulation of the Inflammatory Mediators in the Multifidus Muscle After Spontaneous Intervertebral Disc Degeneration SPARC-null Mice is Ameliorated by Physical Activity. Spine. 2018 Oct 15;43(20):E1184-E1194. doi: 10.1097/BRS.0000000000002656. [link]
  • Fitzcharles MA, Shir Y, Häuser W. Medical cannabis: strengthening evidence in the face of hype and public pressure. CMAJ. 2019 Aug 19;191(33):E907-E908 [link]
  • Ferland CE, Teles AR, Ingelmo P, Saran N, Marchand S, Ouellet JA Blood monoamines as potential biomarkers for conditioned pain modulation efficacy: An exploratory study in paediatrics. Eur J Pain. 2019 Feb;23(2):327-340. doi: 10.1002/ejp.1307 [link]
  • Massart R, Dymov S, Millecamps M, Suderman M, Gregoire S, Koenigs K, Alvarado S, Tajerian M, Stone LS, Szyf M. Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells. Sci Rep. doi: 10.1038/srep19615 (2016) [link]
  • K Herr, PJ Coyne, E Ely, C Gélinas, RCB Manworren Pain Assessment in the Patient Unable to Self-Report: Clinical Practice Recommendations in Support of the ASPMN 2019 Position Statement Pain Management Nursing, 2019 Oct 11. pii: S1524-9042(19)30162-6 [link]
  • Khoutorsky A, Uttam S, Wong C, Price TJ. eIF4E-dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity Front. Genet. | doi: 10.3389/fgene.2018.00470 [link]
  • Martel MO, Petersen K, Cornelius M, Arendt-Nielsen L, Edwards R. Endogenous pain modulation profiles among individuals with chronic pain: Relation to opioid use. J Pain. 2018 Oct 29. pii: S1526-5900(18)30759-4. doi: 10.1016/j.jpain.2018.10.004. [link]
  • He BH, Christin M, Mouchbahani-Constance S, Davidova A, Sharif-Naeini R, Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis Osteoarthritis and Cartilage, Dec. 2017, 25(12):2091-2099 [link]
  • Zidarov D, Zidarova-Carrié A, Visca R, Miller JM, Brecht K, Viens N, Ahmed S. Core patient-reported outcome domains for routine clinical care in chronic pain management: patients' and healthcare professionals' perspective. Qual Life Res. 2020 Mar 3. doi: 10.1007/s11136-020-02459-9. [link]
  • Woznowski-Vu A, Uddin Z, Flegg D, Aternali A, Wickens R, Sullivan MJL, Sweet SN, Skou ST, Wideman TH.Comparing Novel and Existing Measures of Sensitivity to Physical Activity among People With Chronic Musculoskeletal Pain: The Importance of Tailoring Activity to Pain. Clin J Pain. 2019 May 27. doi: 10.1097/AJP.0000000000000732 [link]
  • Khoury S, Piltonen MH, Ton AT, Cole T, Samoshkin A, Smith SB, Belfer I, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, Neely GG, Serohijos AWR, Diatchenko L. A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway. Ann Neurol. 2019 Jun 8. doi: 10.1002/ana.25521 [link]
  • Benavides R, Vsevolozhskaya O, Cattaneo S, Zaykin D, Brenton A, Parisien M, Verma V, Khoury S, Gilron I, Diatchenko L. A functional polymorphism in the ABCB1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. Pain. 2019 Nov 11. doi: 10.1097/j.pain.0000000000001750 [link]
  • Fulas OA, Laferriere A, Stein RS, Bohle DS, Coderre TJ. Topical combination of meldonium and N-acetyl cysteine relieves allodynia in rat models of CRPS-1 and peripheral neuropathic pain by enhancing NO-mediated tissue oxygenation. J Neurochem. 2019 Dec 19:e14943. doi: 10.1111/jnc.14943 [link]
  • Caseiro M, Woznowski-Vu A, De Oliveira AS, Reis FJJ, Wideman TH. From Paper to Digitalized Body Map: A Reliability Study of the Pain Area. Pain Pract. 2019 Jul;19(6):602-608. doi: 10.1111/papr.12780. Epub 2019 Apr 11. [link]
  • Tansley, S.N., Macintyre, L. C., Diamond, L., Sotocinal, S.G., George, N., Meluban, L., Austin, J-S., Coderre, T.J., Martin, L.J.,Mogil, J.S.Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity PAIN: December 03, 2018, doi: 10.1097/j.pain.0000000000001454 [link]
  • Ehrlich AT, Kieffer BL, Darcq E Current strategies toward safer mu opioid receptor drugs for pain management Expert Opin Ther Targets. 2019 Feb 25. doi: 10.1080/14728222.2019.1586882 [link]
  • Gobbi G, Atkin T, Zytynski T, Wang S, Askari S, Boruff J, Ware M, Marmorstein N, Cipriani A, Dendukuri N, Mayo N. Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis JAMA Psychiatry. 2019 Feb 13. doi: 10.1001/jamapsychiatry.2018.4500 [link]
  • Parisien, Marc, Samoshkin, Alexander, Tansley, Shannon N, Piltonen, Marjo H, Martin, Loren J, El-Hachem, Nehme, Dagostino, Concetta, Allegri, Massimo, Mogil, Jeffrey S, Khoutorsky, Arkady,Diatchenko, Luda. Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain PAIN: January 03, 2019 - in Press. doi: 10.1097/j.pain.0000000000001471 [link]
  • Ihab Daou, Hlne Beaudry, Ariel R. Ase, Jeffrey S. Wieskopf, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Philippe Sgula Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain DOI: 10.1523/ENEURO.0140-15 (2016) [link] [File]
  • LE Lorenzo, AG. Godin, F Ferrini, K Bachand, I Plasencia-Fernandez, S Labrecque, AA. Girard, D Boudreau, I Kianicka, M Gagnon, N Doyon, A Ribeiro-da-Silva, Y De Koninck. Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain Nat Commun. 2020 Feb 13;11(1):869. doi: 10.1038/s41467-019-14154-6. [link]
  • James G, Klyne DM, Millecamps M, Stone LS, Hodges PW.ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. Eur Spine J. 2019 Feb 8. doi: 10.1007/s00586-019-05902-9. [link]
  • Wideman TH, Edwards RR, Walton DM, Martel MO, Hudon A, Seminowicz DA. The Multi-modal Assessment Model of Pain: A Novel Framework for Further Integrating the Subjective Pain Experience within Research and Practice. Clin J Pain. 2018 Nov 15. doi: 10.1097/AJP.0000000000000670 [link]
  • Coderre TJ, Topical drug therapeutics for neuropathic pain. Expert Opin Pharmacother. Aug 2018. 19(11):1211-1220. doi: 10.1080/14656566.2018.1501026. [link]
  • Bertolizio G, Otis A, Tam K, Aswar S, Garbin M, Ingelmo P. Multimodal Analgesic Plan for Children Undergoing Chimeric 14.18 Immunotherapy. J Pediatr Hematol Oncol. 2020 Jan 17. doi: 10.1097/MPH.0000000000001722 [link]
  • Ware M.A., Martel M.O., Jovey R., Lynch M.E., Singer J. A prospective observational study of problematic oral cannabinoid use. Psychopharmacology (Berl). 2018 Feb;235(2):409-417. doi: 10.1007/s00213-017-4811-6. Epub 2017 Dec 17. [link]
  • Pomares FB, Roy S, Funck T, Feier NA, Thiel A, Fitzcharles MA, Schweinhardt P. Up-regulation of cortical GABAA receptor concentration in fibromyalgia. Pain. 2019 Sep 27. doi: 10.1097/j.pain.0000000000001707. [link]
  • Huser W, Sarzi-Puttini P, Fitzcharles MA. Fibromyalgia syndrome: under-, over- and misdiagnosis Clin Exp Rheumatol. 2019 Jan-Feb;37 Suppl 116(1):90-97. Epub 2019 Feb 8 [link]
  • Glinas C., Boitor M., Puntillo K.A., Arbour C., Topolovec-Vranic J., Cusimano M.D., Choinire M., Streiner D.L. Behaviors indicative of pain in brain-injured adult patients with different levels of consciousness in the intensive care unit. J Pain Symptom Manage. 2018 Dec 26. pii: S0885-3924(18)31481-7. doi: 10.1016/j.jpainsymman.2018.12.333 [link]
  • Zorina-Lichtenwalter K, Maixner W, Diatchenko L. Detangling red hair from pain: phenotype-specific contributions from different genetic variants in melanocortin-1 receptor. Pain. 2019 Dec 11. doi: 10.1097/j.pain.0000000000001780 [link]
  • Devlin JW, Skrobki Y, Gelinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-e873. doi: 10.1097 [link]
  • Smith SB et al. Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain. 2018 Nov 13. doi: 10.1097/j.pain.0000000000001438 [link]
  • Yakobov E., Suso-Ribera C., Vrinceanu T., Adams H., Sullivan MJL. Trait perceived injustice is associated with pain intensity and pain behaviour in participants undergoing an experimental pain induction procedureJ Pain, Nov 2018, https://doi.org/10.1016/j.jpain.2018.11.007 [link]
  • Häuser W, Welsch P, Klose P, Radbruch L, Fitzcharles MA. Efficacy, tolerability and safety of cannabis-based medicines for cancer pain : A systematic review with meta-analysis of randomised controlled trials. Schmerz. 2019 Oct;33(5):424-436. doi: 10.1007/s00482-019-0373-3. [link]
  • Grégoire S, Jang SH, Szyf M, Stone LS. Prenatal maternal stress is associated with increased sensitivity to neuropathic pain and sex-specific changes in supraspinal mRNA expression of epigenetic- and stress-related genes in adulthood. Behav Brain Res. 2019 Nov 28:112396. doi: 10.1016/j.bbr.2019.112396. [link]
  • Coderre TJ, Laferrière A., The emergence of animal models of chronic pain and logistical and methodological issues concerning their use. Neural Transm (Vienna). 2019 Nov 18. doi: 10.1007/s00702-019-02103-y. [link]
  • Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ. Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain. J Neurosci. 2019 Jan 16;39(3):393-411 [link]
  • Roy M, Vachon-Presseau É. Cortisol increases visceral pain in women but not in men. Pain. 2019 Aug;160(8):1691-1692. [link]
  • Vlaeyen JWS, Maher CG, Wiech K, Van Zundert J, Meloto CB, Diatchenko L, Battié MC, Goossens M, Koes B, Linton SJ. Low back pain Nat Rev Dis Primers. 2018 Dec 13;4(1):52. doi: 10.1038/s41572-018-0052-1. [link]
  • George NC, Laferriere A, Coderre T. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019 Mar 11:1744806919840582. doi: 10.1177/1744806919840582 [link]
  • López-Canul M, Min SH, Posa L, De Gregorio D, Bedini A, Spadoni G, Gobbi G, Comai S. Melatonin MT1 and MT2 Receptors Exhibit Distinct Effects in the Modulation of Body Temperature across the Light/Dark Cycle. Int J Mol Sci. 2019 May 17;20(10). pii: E2452. doi: 10.3390/ijms20102452. [link]
  • Pagé MG, Ziemianski D, Martel MO, Shir Y. Development and validation of the Treatment Expectations in Chronic Pain Scale. Br J Health Psychol. 2019 Sep;24(3):610-628. doi: 10.1111/bjhp.12371 [link]
  • Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, Haglund L, Ouellet JA, Stone LS, Samson J, Smith MJ, Ask K, Ribeiro-da-Silva A, Blunck R, Poole K, Bourinet E, Sharif-Naeini R TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 2020 Feb 17. pii: S0092-8674(20)30114-8. doi: 10.1016/j.cell.2020.01.033. [link]
  • Mogil, JS. The translatability of pain across species. Philos Trans R Soc Lond B Biol Sci. 2019 Nov 11;374(1785):20190286. doi: 10.1098/rstb.2019.0286 [link]
  • Kathleen Vincent, Virginia M. Cornea, Yuh-Jiin I. Jong, Andr Laferrire, Naresh Kumar, Aiste Mickeviciute, Jollee S. T. Fung, Pouya Bandegi, Alfredo Ribeiro-da-Silva, Karen L. OMalley & Terence J. Coderre Intracellular mGluR5 plays a critical role in neuropathic pain doi:10.1038/ncomms10604 (2016) [link]
  • Cordeiro Matos S, Zamfir M, Longo G, Ribeiro-da-Silva A, Sgula P. Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex Brain Struct Funct.doi: 10.1007/s00429-017-1543-7 (Nov 2017) [link]
  • Minerbi A, Gonzalez E, Brereton NJB, Anjarkouchian A, Dewar K, Fitzcharles MA, Chevalier S, Shir Y. Altered microbiome composition in individuals with fibromyalgia. Pain. 2019 Jun 18. doi: 10.1097/j.pain.0000000000001640 [link]
  • Roy, M., Vachon-Presseau, E. Cortisol increases visceral pain in women but not in men. Pain. 2019 Apr 6. doi: 10.1097/j.pain.0000000000001580 [link]
  • Martin LJ, Acland EL, Cho C, Gandhi W, Chen D, Corley E, Kadoura B, Levy T, Mirali S, Tohyama S, Khan S, MacIntyre LC, Carlson EN, Schweinhardt P, Mogil JS. Male-Specific Conditioned Pain Hypersensitivity in Mice and Humans. Curr Biol. 2019 Jan 21;29(2):192-201.e4. doi: 10.1016/j.cub.2018.11.030. Epub 2019 Jan 10 [link]
  • Hodges PW, Barbe MF, Loggia ML, Nijs J, Stone LS. Diverse Role of Biological Plasticity in Low Back Pain and Its Impact on Sensorimotor Control of the Spine. J Orthop Sports Phys Ther. 2019 Jun;49(6):389-401. doi: 10.2519/jospt.2019.8716 [link]
  • Verma V, Khoury S, Parisien M, Cho C, Maixner W, Martin LJ, Diatchenko L. The dichotomous role of epiregulin in pain. Pain. 2020 Jan 7. doi: 10.1097/j.pain.0000000000001792 [link]
  • Anne-Kathrin Brascher, Susanne Becker, Marie-Eve Hoeppli, Petra Schweinhardt Different Brain Circuitries Mediating Controllable and Uncontrollable Pain The Journal of Neuroscience 36(18):50135025 (2016) [link]
  • Federico CA, Wang T, Doussau A, Mogil JS, Fergusson D, Kimmelman J. Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review. JAMA Intern Med. 2019 Jan 1;179(1):90-97. [link]
  • Deslauriers S, Roy JS, Bernatsky S, Feldman DE, Pinard AM, Desmeules F, Fitzcharles MA, Perreault K. Factors associated with waiting times for persons with rheumatic conditions in multidisciplinary pain treatment facilities. J Pain Res. 2019 Jul 30;12:2379-2390. doi: 10.2147 [link]
  • Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Mar 15;14:47-57. doi: 10.1016/j.isci.2019.03.011 [link]
  • Mouchbahani-Constance S, Lesperance, LS, Petitjean H,Davidova A, Macpherson A, Prescott SA, Sharif-Naeini R. Lionfish Venom Elicits Pain Predominantly Through the Activation of Non-Peptidergic Nociceptors PAIN: June 29, 2018, doi: 10.1097/j.pain.0000000000001326 [link]
  • Piltonen M, Parisien M, Grgoire S, Chabot-Dor AJ, Jafarnejad SM, Brub P, Djambazian H, Sladek R, Geneau G, Willett P, Stone LS, Shabalina SA, Diatchenko L. Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms Mol Neurobiol. 2018 Jul 31. doi: 10.1007/s12035-018-1253-z. [link]
  • Beaudry H, Daou I, Ase AR, Ribeiro-da-Silva A, Sgula P. Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers Pain. 2017 Dec;158(12):2329-2339. doi: 10.1097/j.pain.0000000000001016 [link]
  • Tuttle AH, Philip VM, Chesler EJ, Mogil JS.Comparing phenotypic variation between inbred and outbred mice.Nat Methods. 2018 Dec;15(12):994-996. doi: 10.1038/s41592-018-0224-7. [link]
  • Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human disease. Nat Rev Mol Cell Biol. 2018 Jul 23. doi: 10.1038/s41580-018-0034-x [link]
  • Khoutorsky A, Price TJ. Translational Control Mechanisms in Persistent Pain Trends Neurosci. 2017 Dec 14. pii: S0166-2236(17)30233-3. doi: 10.1016/j.tins.2017.11.006 [link]
  • Baird R, Ingelmo P, Wei A, Meghani Y, Perez EV, Pelletier H, Auer G, Mujallid R, Emil S, Laberge JM, Puligandla P, Shaw K, Poenaru D. Nebulized analgesia during laparoscopic appendectomy (NALA): A randomized triple-blind placebo controlled trial J Pediatr Surg. 2019 Jan;54(1):33-38. doi: 10.1016/j.jpedsurg.2018.10.029 [link]
  • Petitjean H, B Bourojeni F, Tsao D, Davidova A, Sotocinal SG, Mogil JS, Kania A, Sharif-Naeini R. Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons Cell Rep. 2019 Aug 6;28(6):1429-1438.e4 [link]
  • Mohand-Saïd S, Lalonde MR, Boitor M, Gélinas C. Family Members' Experiences with Observing Pain Behaviors Using the Critical-Care Pain Observation Tool. Pain Manag Nurs. 2019 May 17. pii: S1524-9042(18)30233-9 [link]
  • Krock E, Millecamps M, Anderson KM, Srivastava A, Reihsen TE, Hari P, Sun YR, Jang SH, Wilcox GL, Belani KG, Beebe DS, Ouellet J, Pinto MR, Kehl LJ, Haglund L, Stone LS. Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine. 2019 Apr 29. pii: S2352-3964(19)30271-3. [link]
  • Hochberg U, Ojeda A, Brill S, Perez J An internet based survey to assess clinicians' knowledge and attitudes towards opioid induced hypogonadism. Pain Pract. 2018 Sep 30. doi: 10.1111/papr.12731. [link]